Chances are, space will get you killed. Make smart tactical decisions and you just might save the human race. Play recklessly and humanity dies with you.
Your ship’s artificial intelligence just might go insane. The thruster reactors leak and the hull is cracking from the stress of intergalactic flight. Your robots need constant maintenance, and pesky nanobots are trying to corrupt the creation engines and break the ship apart. Manage your resources carefully or there’s no tomorrow.
Every member of your crew has been engineered to give the arkship a special power. Activate those powers by connecting crew to the ship’s artificial intelligence (interfacing).
Assign non-interfaced crew to shifts. Every crew member is armed with a different speciality to deal with the arkship’s growing list of problems. Decide who’s on shift and when to keep the arkship from falling apart. But be warned, your symbiotic crew members will grow fatigued if you keep them from interfacing with the artificial intelligence for too long.
Look, space is a very big place. There’s no reason to play (or die) in the same place twice.